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Our research publications

These are research publications from our staff.
Jean-Pierre Chanoine, MD (top)

Daniel L. Metzger, MD, FAAP, FRCPC (top)

  • Wang X, Hao J, Metzger DL, Ao Z, Verchere CB, Chen L, Ou D, Mui A, Warnock GL. B7-H4 treatment of T cells inhibits ERK, JNK, and AKT activation. PLoS ONE 2012;7(1):e28232.
  • Wang X, Hao J, Metzger DL, Mui M, Ao Z, Akhoundsadegh N, Langermann S, Liu L, Chen L, Ou D, Verchere CB, Warnock GL. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes 2011;60(12):3246–3255.
  • Wang X, Hao J, Metzger DL, Ao Z, Meloche M, Verchere CB, Chen L, Ou D, Mui AL, Warnock GL. B7-H4 pathway in islet transplantation and β-cell replacement therapies. Journal of Transplantation, Volume 2011, Article ID 418902, 8 pages.
  • Levine DS, Metzger DL, Nadel HR, Oviedo A, Adam MJ, Skarsgard E. Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatric Radiolology 2011;41(10):1321–1325.
  • Amed S, Vanderloo SE, Metzger DL, Collet J-P, Reimer K, McCrea P, Johnson JA. Validation of diabetes case definitions using administrative claims data. Diabetic Medicine 2011;28(4):424–427.
  • Metzger DL. Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol. British Columbia Medical Journal 52(1):24–31, 2010.
  • Peñaherrera MS, Weindler S, Van Allen MI, Yong S-L, Metzger DL, McGillivray B, Boerkoel C, Langlois S, Robinson WP. Methylation profiling in individuals with Russell–Silver syndrome. American Journal of Medical Genetics Part A 152A(2):347–355, 2010.
  • Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation 2009;87(4):482–490.
  • Calado J, Sznajer Y, Metzger DL, Rita A, Hogan MC, Kattamis A, Scharf M, Tasic V, Greil J, Brinkert F, Kemper MJ, Santer R. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrology Dialysis Transplantation 2008;23(12):3874–3879.
  • Bretherick KL, Metzger DL, Chanoine JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics Part A 2007;143(9):945–951.
  • Pitteloud N, Acierno JS Jr, Meysing A, Eliseenkova AV, Ma J, Ibrahimi OA, Metzger DL, Hayes FJ, Dwyer AA, Hughes VA, Yialamas M, Hall JE, Grant E, Mohammadi M, Crowley WF Jr. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proceedings of the National Academy of Sciences of the USA 2006;103(16):6281–6286.
  • Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger DL, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. Journal of the American Society of Nephrology 2006;17(5):1429–1436.
  • Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RFL, Chen L, Warnock GL. Suppression of human T-cell responses to β cells by activation of B7-H4 pathway. Cell Transplantation 2006;15(5):399-410(12).
  • Skowronski DM, Bjornson G, Husain E, Metzger DL, Scheifele DW. Oculo-respiratory syndrome after influenza immunization in children. Pediatric Infectious Disease Journal 2005;24(1)63–69.
  • Cheung SS, Metzger DL, Wang X, Huang J, Tai J, Tingle AJ, Ou D. Tumor necrosis factor–related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus. Pancreas 2005;30(2):105–114.
  • Ou D, Wang X, Metzger DL, James RFL, Pozzilli P, Plesner A, Korneluk RG, Verchere CB, Tingle AJ. Synergistic inhibition of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human pancreatic β cells by Bcl-2 and X-linked inhibitor of apoptosis. Human Immunology 2005;66(3):274–284.
  • Grasberger H, Mimouni–Bloch A, Vantyghem M–C, van Vliet G, Abramowicz M, Metzger DL, Abdullatif H, Rydlewski C, Macchia PE, Scherberg NH, van Sande J, Mimouni M, Weiss RE, Vassart G, Refetoff S. Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci. Journal of Clinical Endocrinology and Metabolism 2005;90(7):4025-4034.
  • Ou D, Wang X, Metzger DL, Robbins M, Huang J, Jobin C, Chantler JK, James RFL, Pozzilli P, Tingle AJ. Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human β cells by Fas-associated death domain and nuclear factor κB. Human Immunology 2005;66(7):799-809.
  • Schlingmann KP, Sassen MC, Weber S, Pechmann U, Kusch K, Pelken L, Lotan D, Syrrou M, Prebble JJ, Cole DE, Metzger DL, Rahman S, Tajima T, Shu SG, Waldegger S, Seyberth HW, Konrad M. Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. Journal of the American Society of Nephrology 2005;16(10):3061–3069.
  • Ortiz–Alvarez O, Metzger DL, Malleson PN, Cabral DA, Tucker LB, Petty RE. Addison's disease in a child with systemic lupus erythematosus. Pediatric Rheumatology Online Journal 2004;2(2):134–139.
  • McKinney JL, Cao H, Robinson JF, Metzger DL, Cummings E, Riddell DC, Sanderson SR, Pacaud D, Ho J, Hegele RA. Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY). Clinical and Investigative Medicine 2004;27(3):129–134.
  • Metzger DL. Current approaches to the prevention of type 1 diabetes. British Columbia Medical Journal 2004;46(9):446–450.
  • Bradley TJ, Hosking MCK, Metzger DL, Sanatani S. Long on QT and low on calcium. Cardiology in the Young 2004;14(6):667–670.
  • Panagiotopoulos C, Preston JM, Stewart LL, Metzger DL, Chanoine JP. Weekly telephone contact by a diabetes educator in adolescents with type 1 diabetes. Canadian Journal of Diabetes 2003;27(4):422–427.
  • Ou D, Metzger DL, Wang X, Pozzilli P, Tingle AJ. β-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: autoaggressive CD56+ β cells by HLA-restricted and non-HLA-restricted pathways. Human Immunology 2002;63(4)256–270.
  • Cao H, Shorey S, Robinson J, Metzger DL, Stewart L, Cummings E, Hegele RA. GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young. Human Mutation 2002;20(6):478-479 (Mutation in Brief #561).
  • Ou D, Metzger DL, Wang X, Huang J, Pozzilli P, Tingle AJ. TNF-related apotosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 2002;45(12):1678–1688.
  • Diabetes Prevention Trial—Type 1 Diabetes Study Group [Metzger DL, Study Group Member]. Effects of insulin in relatives of patients with type 1 diabetes mellitus. New England Journal of Medicine 2002;346(22):1685-1691.
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2001;15(5):297–301.
  • Sandrini F, Farmakidis C, Kirschner LS, Wu S-M, Tullio-Pelet A, Lyonnet S, Metzger DL, Bourdony CJ, Tiosano D, Chan W-Y, Stratakis CA. Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticosteroids. Journal of Clinical Endocrinology & Metabolism 2001;86(11):5433–5437.
  • Zhang Y-H, Huang B-L, Anyane-Yeboa K, Carvahlo JAR, Clemons RD, Cole T, De Figueiredo BC, Lubinsky M, Metzger DL, Quadrelli R, Repaske DR, Reyno S, Seaver LH, Vaglio A, Van Vliet G, McCabe LL, McCabe ERB, Phelan JK. Nine novel mutations in NRB01 (DAX1) causing adrenal hypoplasia congenita. Human Mutation 2001;18(6):547 (Mutation in Brief #463).
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2000;14(11):915–918.
  • Bjornson G, Scheifele D, Metzger DL, Ferguson A, Wensley D, Whitfield M. Promoting the use of influenza vaccine for children at risk of complications. British Columbia Medical Journal 2000;42(2):89–90.
  • Ou D, Mitchell LA, Metzger DL, Gillam S, Tingle AJ.Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus. Diabetologia 2000;43(6):750–762.
  • Ou D, Jonson LA, Metzger DL, Tingle AJ. CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: implications for HLA class I and II allelic linkage to disease susceptibility. Human Immunology 1999;60(8):652–664.
  • Metzger DL, Kerrigan JR. Sex-steroid-hormone modulation of the somatotropic axis during normal male puberty. In: Veldhuis JD, Giustina A, eds. Serono Symposia USA: Sex-steroid interactions with growth hormone. New York: Springer-Verlag, 1999.
  • Travitz J, Metzger DL. Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues. Genetics in Medicine 1999;1(5):224–230.
  • Metzger DL. A provincial protocol for the treatment of diabetic ketoacidosis in children. British Columbia Medical Journal 1998;40(3):110–114.
  • Metzger DL, Kerrigan JR, Rogol AD. The short-term administration of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men. Journal of Clinical Endocrinology & Metabolism 1997;82(2):692–700.
  • Veldhuis JD, Metzger DL, Martha Jr. PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. Journal of Clinical Endocrinology & Metabolism 1997;82(10):3414–3420.
Laura Stewart, MD, FRCPC (top)

Constadina Panagiotopoulos, MD, FRCPC (top)

Shazhan Amed, MD, FRCPC, FAAP (top)

  • Amed S, Dean H, Sellers EA, Panagiotopoulos C, Shah BR, Booth GL, Laubscher TA, Dannenbaum D, Hadjiyannakis S, Hamilton JK. Risk factors for medication-induced diabetes and type 2 diabetes. Journal of Pediatrics 2011;159(2):291–296.
  • Amed S, Vanderloo SE, Metzger DL, Collet J-P, Reimer K, McCrea P, Johnson JA. Validation of diabetes case definitions using administrative claims data. Diabetic Medicine 2011;28(4):424–427.
  • Amed S, Dean HJ, Panagiotopoulos C, Sellers EAC, Hadjiyanakis S, Laubscher TA, Dannenbaum D, Shah BR, Booth GL, Hamilton JK. Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study. Diabetes Care 2010;33(4):786–791.
  • Amed S, Daneman D, Mahmud FH, Hamilton J. Type 2 diabetes in children and adolescents. Expert Review of Cardiovascular Therapy 2010;8(3):393–406.
  • Amed S, Delvin E, Hamilton J, on behalf of the Canadian Pediatric Endocrine Group. Variation in growth hormone immunoassays in clinical practice in Canada. Hormone Research 2008;69(5):290–294.
Sue Stock, MD, FRCPC (top)

  • Stock S, Miranda C, Evans S, Plessis S, Ridley J, Yeh S, Chanoine JP. Healthy Buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary school. Pediatrics 2007;120(4):e1059–1068.
  • Stock S, Leichner P, Wong ACK, Ghatei MA, Kieffer TJ, Bloom SR, Chanoine JP. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. Journal of Clinical Endocrinology and Metabolism 2005;90(4):2161–2168.
Ralph R. Rothstein, MD, FRCPC (top)

Sheila Kelton, RN, BScN (top)

Janet M. Preston, RN, BSN, CDE (top)

Heather Nichol, RN, MScN, CDE (top)

Cristina Pepe, RN, BSN, CDE (top)

Page Last Updated: 27 January 2012