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Rheumatology

We are currently enrolling participants for rheumatology studies. Read about the studies here.

Juvenile Idiopathic Arthritis (JIA) Studies  

PREVENT-JIA
The PREVENT study is being headed by Dr. Dirk Foell at the University of Münster, Germany, and our pediatric rheumatology team at BCCH will be collaborators in the project. In this study, investigators will be looking at a new biomarker in the blood of children with JIA which has promise for predicting disease flares. In particular, we will be trying to determine whether this biomarker will help predict the risk of disease flare after a child with JIA is taken off medications because their disease is felt to be in clinical remission. Click here for more information on PREVENT.

Systemic Lupus Erythematosus (SLE) Studies

PedANAM: Studying the Pediatric ANAM in pSLE 
Ped-Automated Neuropsychological Assessment Metrics (PedANAM) is a specialized computer program used to measure cognitive function, and has been adapted to be used in children and teens. As SLE can cause impairments in learning, thinking, and memory the PedANAM study is looking at teens with SLE to see if using this simple computer test in the routine clinic visit is feasible and can show changes in brain functioning over time. The PedANAM study is being conducted in approximately 17 hospitals in Canada and the United States. Dr. Lori Tucker heads the PedANAM study at BC Children’s Hospital.

Vasculitis Studies

PedVas: The Pediatric Vasculitis Initiative
PedVas logo.PNG
The PedVas study is an international study, headed by Dr. David Cabral, based at BC Children’s Hospital and includes collaborators in Canada, US, and various countries across the globe. The project is funded by the Canadian Institutes of Health Research (CIHR). This study is examining childhood chronic vasculitis, a set of inflammatory diseases affecting blood vessels in body organs such as the kidneys, lungs and brain. Through the PedVas study Dr. Cabral and his colleagues hope to learn more about pediatric vasculitis and improve the diagnosing and treatment of vasculitis in children and adolescents. You can read more about PedVas on the clinicaltrials.gov website.

Autoinflammatory Disease Studies

  • CAN-Fever Registry
    Compared to other diseases in kids, autoinflammatory diseases are rare and haven't been studied as much. The purpose of this registry is to develop a collection of information about autoinflammatory diseases in kids in order to better understand and better treat these diseases. Researches will be able to use the registry as a tool to help determine what sort of research questions are important to study. Children diagnosed with any type of autoinflammatory disease may be eligible for this study.

  • 60 Days of iThermonitoring
  • Periodic fevers are often difficult to identify as symptoms can look like a common infection. Therefore many children suffer for several years before physicians recognize their real problem. Even with a diagnosis, there are so far no satisfying treatment guidelines and as a result the affected children are at significant risk for lifelong poor health and disability. At the pediatric rheumatology clinic at BCCH, we are trying to fill in the knowledge gaps associated with periodic fevers in children. In this study we are searching for inflammatory proteins measured in non-invasive samples (saliva and urine) that can help physicians to faster set a correct diagnose and inform about the progression of the disease. We will also be asking families to test a wireless thermometer for monitoring their child's temperature. Children diagnosed with PFAPA and are having active episodes may be eligible for this study.


  • Clinical Drug Trials

    Tofacitinib for Children with Juvenile Idiopathic Arthritis

    This clinical trial is being conducted to study a new drug called Tofacitinib.  We want to determine how safe and effective it is in children with Juvenile Iidiopathic Arthritis compared to placebo (a compound that looks like Tofacitinib but has no active medicine in it). Children who are diagnosed with Oligoarthritis (extended), Polyarthritis, Systemic JIA, Psioratic arthritis, or Enthesitis-related arthritis may be eligible to participate in this study. You can read more about the study on clinicaltrials.gov.

    Abatacept Registry
    The Abatacept Registry study is being conducted at over 90 research centres all over the world to learn more about the long-term safety of the medication Abatacept (Orencia) and to see if it has good or bad effects on JIA. Patients who have been diagnosed with JIA and are taking Abatacept are eligible to participate in this study.

    Upcoming Research Studies

    Recruitment for these studies will start in the near future. Talk to any member of the research team to find out more information and see if you are eligible to join!

    SOURCE: Rheumatology ( )
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