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Endocrinology & Diabetes

We have an active program for both basic science research and clinical research.
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Our researchers

Our BC Children's Hospital Research Institute research profiles:

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Publications

Publications from our staff

 

 
  • Alsaeed H, Metzger DL, Blydt-Hansen TD, Rodd CJ, Sharma A. Isolated diastolic high blood pressure: a distinct clinical phenotype in US children. Pediatric Research 27 January 2021 [advanced publication].
  • D’Alessandro PR, Hamilton J, Khatchadourian K, Lunaczek-Motyka E, Schultz KR, Metzger DL, Deyell RJ. Precocious puberty: a red flag for malignancy in childhood. BC Medical Journal 2021;63(6):242–246.
  • Robinson SK, Rodd CJ, Metzger DL, Sharma AK. Prevalence of high blood pressure among Canadian children: 2017 American Academy of Pediatric guidelines with the Canadian Health Measures Survey. Paediatrics & Child Health 2021;26(3):e158–e165.
  • McGregor S, Metzger DL, Amed S, Goldman RD. Fluid management in children with diabetic ketoacidosis. Canadian Family Physician 2020;66(11):817-819.
  • Solimano A, Osiovich H, Kwan E, Metzger DL, Everett R. Are there alternatives to over-the-counter diabetes-care dextrose-gels for transitional neonatal hypoglycemia? Paediatrics & Child Health 2021;26(1):4–7.
  • Ronsley R, Islam N, Kang M, Nadel H, Reilly C, Metzger DL, Selby K, Panagiotopoulos C. Effects of bisphosphonate therapy on bone mineral density in boys with Duchenne muscular dystrophy. Clinical Medicine Insights: Endocrinology and Diabetes 2020;13:1–8.
  • Glackin S, Metzger DL, Hanas R, Chanoine JP. Is age a risk factor for cerebral edema in children with diabetic ketoacidosis? A literature review. Canadian Journal of Diabetes 2020;44(1):111–118.
  • Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group [Metzger DL, Study Group Member]. A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk. Diabetes Care 2018;41(9):1887–1894.
  • Guan L, Metzger DL, Lavoie PM, Collet JP. Glucose control and autonomic response during acute stress in youth with type 1 diabetes: a pilot study. Pediatric Diabetes 2018;19(5):1020–1024.
  • Sharma AK, Metzger DL, Rodd CJ. Increased prevalence and severity of high blood pressures in children using the 2017 AAP guidelines: a case-control study to characterize the new disease burden. JAMA Pediatrics 2018;172(6):557-565.
  • Rodd CJ, Metzger DL, Sharma AK. WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting. Paediatrics & Child Health 2018;23(3):176–178.
  • Ronsley R, Islam N, Ronsley C, Metzger DL, Panagiotopoulos C. Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital. Pediatric Diabetes 2018;19(2):333–338.
  • Writing Group for the TRIGR Study Group [Metzger DL, Study Group Member]. Effect of hydrolyzed infant formula vs conventional formula on risk of type 1 diabetes: the TRIGR randomized clinical trial. JAMA 2018;319(1):38–48.
  • Wong EM, Lehman A, Acott P, Gillis J, Metzger DL, Sirrs S. Hypogonadotropic hypogonadism in males with glycogen storage disease type 1. Journal of Inherited Metabolic Disorders Reports 2017:36:79–84.
  • Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Yea XC, Zhang LH, Bhavsar AP, Lee JJY, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger DL, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD. Exome sequencing and the management of neurometabolic disorders. New England Journal of Medicine 2016;374(23):2246–2255.
  • Daly AF, Yuan B, Fina F, Caberg J-H, Trivellin G, Rostomyan L, de Herder WW, Naves LA, Metzger DL, Cuny T, Rabl W, Shah N, Jaffrain-Rea M-L, Zatelli MC, Faucz FR, Castermans E, Nanni-Metellus I, Lodish M, Muhammad A, Palmeira L, Potorac I, Mantovani G, Neggers SJ, Klein M, Barlier M, Liu P, Ouafik L, Bours V, Lupski JR , Stratakis CA, Beckers A. Somatic mosaicism underlies X-linked acrogigantism (XLAG) syndrome in sporadic male subjects. Endocrine-Related Cancer 2016;23(4):221–233.
  • Sharma AK, Metzger DL, Daymont C, Hadjiyannakis S, Rodd CJ. LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks. Pediatric Research 2015;78(6):723–729.
  • Veale J, Saewyc E, Frohard-Dourlent H, Dobson S, Clark B and the Canadian Trans Youth Health Survey Research Group. Being Safe, Being Me: Results of the Canadian Trans Youth Health Survey. Vancouver, BC: Stigma and Resilience Among Vulnerable Youth Centre, School of Nursing, University of British Columbia 2015 (Co-Investigator).
  • Beckers A, Lodish MB, Trivellin G, Rostomyan L, Lee M, Faucz FR, Yuan B, Choong CS, Caberg J-H, Verrua E, Naves LA, Cheetham TD, Young J, Lysy PA, Petrossians P, Cotterill A, Shah NS, Metzger DL, Castermans E, Ambrosio MR, Villa C, Strebkova N, Mazerkina N, Gaillard S, Barcelos Barra G, Casulari LA, Neggers SJ, Salvatori R, Jaffrain-Rea M-L, Zacharin M, Lecumberri Santamaria B, Zacharieva S, Lim EM, Mantovani G, Zatelli MC, Collins MT, Bonneville J-F, Quezado M, Chittiboina P, Oldfield EH, Bours V, Liu P, de Herder WW, Pellegata N, Lupski JR, Daly F, Stratakis, CA. X-linked acrogigantism (X-LAG) syndrome: clinical profile and therapeutic responses. Endocrine-Related Cancer 2015;22(3):353–367.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C. Use of growth charts in Canada: a National Canadian Paediatric Surveillance Program survey. Paediatrics & Child Health 2015;20(4):185–188.
  • Lawrence SE, Cummings EA, Pacaud D, Lynk A, Metzger DL. Joint Position Statement from the Canadian Paediatric Society and the Canadian Pediatric Endocrine Group. Managing type 1 diabetes in school: recommendations for policy and practice. Paediatrics & Child Health 2015:20(1):35–39.
  • Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. New England Journal of Medicine 2014;371(25):2363–2374.
  • Li D, Opas EE, Tuluc F, Metzger DL, Hou C, Hakonarson H, Levine MA. Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization. Journal of Clinical Endocrinology and Metabolism 2014;99(9):E1774–1783.
  • Hasan H, Howard AF, Metzger DL, Gill S, Johnson M, Lo AC, Goddard K. Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height. British Columbia Medical Journal 2014;56(5):230–235.
  • Hasan H, Howard F, Morgan SG, Metzger DL, Lo AC, Goddard K. Provincial disparities of growth hormone coverage for adult survivors of paediatric brain tumours across Canada. Healthcare Policy 2014;9(3):80–96.
  • Khatchadourian K, Amed S, Metzger DL. Clinical management of youth with gender dysphoria in Vancouver. Journal of Pediatrics 2014;164(4):906–911.
  • Rodd C, Metzger DL, Sharma A, for the Canadian Pediatric Endocrine Group Working Committee for National Growth Charts. Extending WHO weight-for-age reference curves to older children. BMC Pediatrics 2014;14:32.
  • Cheung SSC, Ou D, Metzger DL, Meloche M, Ao Z, Ng SSW, Owen D, Warnock GL. B7-H4 expression in normal and diseased human islet β cells. Pancreas 2014;43(1):128–134.
  • Inman M, Hursh BE, Mokashi A, Pinto T, Metzger DL, Cummings EA. Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty. Hormone Research in Paediatrics 2013;80(1):64–68.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C, on behalf of the Canadian Pediatric Endocrine Group. Canadian Pediatric Endocrine Group extension to WHO growth charts: why bother? Paediatrics & Child Health 2013;18(6):295–297.
  • Malhotra N, Khatchadourian K, Metzger DL, Lam JM. Clinician’ Corner. Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones. Paediatrics & Child Health 2013;18(2):91–93.
  • Wang X, Hao J, Metzger DL, Mui A, Lee I-F, Akhoundsadegh N, Ao Z, Chen L, Ou D, Verchere CB, Warnock GL. Endogenous expression of B7-H4 improves long term murine islet allograft survival. Transplantation 2013;95(1):94–99.
  • Wang X, Hao J, Metzger DL, Mui A, Lee I-F, Akhoundsadegh N, Chen LC, Ou D, Ao Z, Verchere CB, Warnock GL. Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival. Islets 2012;4(4):1–12.
  • Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano L, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF Jr., Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GNRH receptor (GNRHR). Journal of Clinical Endocrinology and Metabolism 2012;97(9):E1798–E1807.
  • Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. B7-H4 induces donor-specific tolerance in mouse islet allografts. Cell Transplantation 2012;21(1):99–111.
  • Wang X, Metzger DL, Meloche M, Hao J, Ao Z Warnock GL. Generation of transplantable beta cells for patient-specific cell therapy. International Journal of Endocrinology 2012;Article ID 414812, 7 pages.
  • Wang X, Hao J, Metzger DL, Ao Z, Verchere CB, Chen L, Ou D, Mui A, Warnock GL. B7-H4 treatment of T cells inhibits ERK, JNK, and AKT activation. PLoS ONE 2012;7(1):e28232.
  • Wang X, Hao J, Metzger DL, Mui M, Ao Z, Akhoundsadegh N, Langermann S, Liu L, Chen L, Ou D, Verchere CB, Warnock GL. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes 2011;60(12):3246–3255.
  • Wang X, Hao J, Metzger DL, Ao Z, Meloche M, Verchere CB, Chen L, Ou D, Mui AL, Warnock GL. B7-H4 pathway in islet transplantation and β-cell replacement therapies. Journal of Transplantation, 2011:Article ID 418902, 8 pages.
  • Levine DS, Metzger DL, Nadel HR, Oviedo A, Adam MJ, Skarsgard E. Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatric Radiolology 2011;41(10):1321–1325.
  • Amed S, Vanderloo SE, Metzger DL, Collet J-P, Reimer K, McCrea P, Johnson JA. Validation of diabetes case definitions using administrative claims data. Diabetic Medicine 2011;28(4):424–427.
  • Metzger DL. Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol. British Columbia Medical Journal 52(1):24–31, 2010.
  • Peñaherrera MS, Weindler S, Van Allen MI, Yong S-L, Metzger DL, McGillivray B, Boerkoel C, Langlois S, Robinson WP. Methylation profiling in individuals with Russell–Silver syndrome. American Journal of Medical Genetics Part A 152A(2):347–355, 2010.
  • Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation 2009;87(4):482–490.
  • Calado J, Sznajer Y, Metzger DL, Rita A, Hogan MC, Kattamis A, Scharf M, Tasic V, Greil J, Brinkert F, Kemper MJ, Santer R. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrology Dialysis Transplantation 2008;23(12):3874–3879.
  • Bretherick KL, Metzger DL, Chanoine JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics Part A 2007;143(9):945–951.
  • Pitteloud N, Acierno JS Jr, Meysing A, Eliseenkova AV, Ma J, Ibrahimi OA, Metzger DL, Hayes FJ, Dwyer AA, Hughes VA, Yialamas M, Hall JE, Grant E, Mohammadi M, Crowley WF Jr. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proceedings of the National Academy of Sciences of the USA 2006;103(16):6281–6286.
  • Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger DL, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. Journal of the American Society of Nephrology 2006;17(5):1429–1436.
  • Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RFL, Chen L, Warnock GL. Suppression of human T-cell responses to β cells by activation of B7-H4 pathway. Cell Transplantation 2006;15(5):399-410(12).
  • Skowronski DM, Bjornson G, Husain E, Metzger DL, Scheifele DW. Oculo-respiratory syndrome after influenza immunization in children. Pediatric Infectious Disease Journal 2005;24(1)63–69.
  • Cheung SS, Metzger DL, Wang X, Huang J, Tai J, Tingle AJ, Ou D. Tumor necrosis factor–related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus. Pancreas 2005;30(2):105–114.
  • Ou D, Wang X, Metzger DL, James RFL, Pozzilli P, Plesner A, Korneluk RG, Verchere CB, Tingle AJ. Synergistic inhibition of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human pancreatic β cells by Bcl-2 and X-linked inhibitor of apoptosis. Human Immunology 2005;66(3):274–284.
  • Grasberger H, Mimouni–Bloch A, Vantyghem M–C, van Vliet G, Abramowicz M, Metzger DL, Abdullatif H, Rydlewski C, Macchia PE, Scherberg NH, van Sande J, Mimouni M, Weiss RE, Vassart G, Refetoff S. Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci. Journal of Clinical Endocrinology and Metabolism 2005;90(7):4025-4034.
  • Ou D, Wang X, Metzger DL, Robbins M, Huang J, Jobin C, Chantler JK, James RFL, Pozzilli P, Tingle AJ. Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human β cells by Fas-associated death domain and nuclear factor κB. Human Immunology 2005;66(7):799-809.
  • Schlingmann KP, Sassen MC, Weber S, Pechmann U, Kusch K, Pelken L, Lotan D, Syrrou M, Prebble JJ, Cole DE, Metzger DL, Rahman S, Tajima T, Shu SG, Waldegger S, Seyberth HW, Konrad M. Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. Journal of the American Society of Nephrology 2005;16(10):3061–3069.
  • Ortiz–Alvarez O, Metzger DL, Malleson PN, Cabral DA, Tucker LB, Petty RE. Addison's disease in a child with systemic lupus erythematosus. Pediatric Rheumatology Online Journal 2004;2(2):134–139.
  • McKinney JL, Cao H, Robinson JF, Metzger DL, Cummings E, Riddell DC, Sanderson SR, Pacaud D, Ho J, Hegele RA. Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY). Clinical and Investigative Medicine 2004;27(3):129–134.
  • Metzger DL. Current approaches to the prevention of type 1 diabetes. British Columbia Medical Journal 2004;46(9):446–450.
  • Bradley TJ, Hosking MCK, Metzger DL, Sanatani S. Long on QT and low on calcium. Cardiology in the Young 2004;14(6):667–670.
  • Panagiotopoulos C, Preston JM, Stewart LL, Metzger DL, Chanoine JP. Weekly telephone contact by a diabetes educator in adolescents with type 1 diabetes. Canadian Journal of Diabetes 2003;27(4):422–427.
  • Ou D, Metzger DL, Wang X, Pozzilli P, Tingle AJ. β-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: autoaggressive CD56+ β cells by HLA-restricted and non-HLA-restricted pathways. Human Immunology 2002;63(4)256–270.
  • Cao H, Shorey S, Robinson J, Metzger DL, Stewart L, Cummings E, Hegele RA. GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young. Human Mutation 2002;20(6):478-479 (Mutation in Brief #561).
  • Ou D, Metzger DL, Wang X, Huang J, Pozzilli P, Tingle AJ. TNF-related apotosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 2002;45(12):1678–1688.
  • Diabetes Prevention Trial—Type 1 Diabetes Study Group [Metzger DL, Study Group Member]. Effects of insulin in relatives of patients with type 1 diabetes mellitus. New England Journal of Medicine 2002;346(22):1685-1691.
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2001;15(5):297–301.
  • Sandrini F, Farmakidis C, Kirschner LS, Wu S-M, Tullio-Pelet A, Lyonnet S, Metzger DL, Bourdony CJ, Tiosano D, Chan W-Y, Stratakis CA. Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticosteroids. Journal of Clinical Endocrinology & Metabolism 2001;86(11):5433–5437.
  • Zhang Y-H, Huang B-L, Anyane-Yeboa K, Carvahlo JAR, Clemons RD, Cole T, De Figueiredo BC, Lubinsky M, Metzger DL, Quadrelli R, Repaske DR, Reyno S, Seaver LH, Vaglio A, Van Vliet G, McCabe LL, McCabe ERB, Phelan JK. Nine novel mutations in NRB01 (DAX1) causing adrenal hypoplasia congenita. Human Mutation 2001;18(6):547 (Mutation in Brief #463).
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2000;14(11):915–918.
  • Bjornson G, Scheifele D, Metzger DL, Ferguson A, Wensley D, Whitfield M. Promoting the use of influenza vaccine for children at risk of complications. British Columbia Medical Journal 2000;42(2):89–90.
  • Ou D, Mitchell LA, Metzger DL, Gillam S, Tingle AJ.Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus. Diabetologia 2000;43(6):750–762.
  • Ou D, Jonson LA, Metzger DL, Tingle AJ. CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: implications for HLA class I and II allelic linkage to disease susceptibility. Human Immunology 1999;60(8):652–664.
  • Metzger DL, Kerrigan JR. Sex-steroid-hormone modulation of the somatotropic axis during normal male puberty. In: Veldhuis JD, Giustina A, eds. Serono Symposia USA: Sex-steroid interactions with growth hormone. New York: Springer-Verlag, 1999.
  • Travitz J, Metzger DL. Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues. Genetics in Medicine 1999;1(5):224–230.
  • Metzger DL. A provincial protocol for the treatment of diabetic ketoacidosis in children. British Columbia Medical Journal 1998;40(3):110–114.
  • Metzger DL, Kerrigan JR, Rogol AD. The short-term administration of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men. Journal of Clinical Endocrinology & Metabolism 1997;82(2):692–700.
  • Veldhuis JD, Metzger DL, Martha Jr. PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. Journal of Clinical Endocrinology & Metabolism 1997;82(10):3414–3420.
 

 
 

 
 

 
 

 
 

 
 

 
 

 
 
You can help

Support our research & education programs

The Endocrinology & Diabetes Unit participates in a number of research studies at the basic science, clinical and applied levels. Our publication list attests to the breadth of our active research interests. As well, we continue to develop and update educational materials for our patients. Funding for these efforts is derived from governmental and institutional grants, from industry support, and from private donations. These funds can be directed to the project area of the donor's choice.

Endocrine Educational Materials

Our unit has developed a number of booklets and handouts for our patients with endocrine conditions. Many of these resources are used extensively across North America.

Diabetes Educational Materials

Our unit has developed a number of booklets and handouts for our patients with type 1 and type 2 diabetes. Many of these resources are used extensively across North America. Two recent projects are entitled Insulin Dose Adjustment: An Online Education Program for Parents of Children with Diabetes and Taking Care of Diabetes at School.

Diabetes Basic-Science & Clinical Research

Members of our unit work in close collaboration with scientists from the BC Children's Hospital Research Institute. Our areas of focus include: genetics of type 1 diabetes; islet cell biology and transplantation; viral pathogenesis of diabetes; immunology of type 1 diabetes; and clinical diabetes research.

Obesity Basic-Science & Clinical Research

The Chanoine–Alimenti Endowment for Childhood Obesity was established to develop and enhance new research and clinical programs aimed at the prevention and treatment of childhood and adolescent obesity.

All cheques should me made out to the BC Children's Hospital Foundation. Please note on the cheque the specific cause or program for which you are making a donation. If you have further questions about contributing to the research and educational efforts that are being conducted by our division, please contact:

Ms. Janice Williams
British Columbia's Children's Hospital Foundation
938 West 28th Avenue
Vancouver, BC V5Z 4H4 Canada
Phone: 604-875-2677
Fax: 604-875-2596
E-mail: jwilliams@bcchf.ca

We thank you for your interest in our research and educational activities!

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