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Endocrinology & Diabetes

We have an active program for both basic science research and clinical research.
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Our researchers

Our BC Children's Hospital Research Institute research profiles:

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Publications

Publications from our staff

 
  • Damanhoury S, Morrison KM, Mian R, McPhee PG, Kozyrskyj AL, Newton AS, Buchholz A, Chanoine JP, Hamilton J, Ho J, Laberge AM, Legault L, Thabane L, Tremblay MS, Zenlea I, Ball GDC. Metabolically healthy obesity in children enrolled in the CANadian Pediatric Weight management Registry (CANPWR): An exploratory secondary analysis of baseline data. Clinical Obesity 2021 Oct 7;e12490 [online ahead of print].
  • Rowlands A, Deeb A, Ladjouze A, Hamza RT, Musa SA, Raza J, Jennane F, Abu-Libdeh A, Chanoine JP, GPED CAH Working Group. Access to fludrocortisone and to hydrocortisone in children with congenital adrenal hyperplasia in the WHO Eastern Mediterranean Region: it takes a village… British Medical Journal: Global Health 2021;6(10):e007195.
  • McPhee PG, Zenlea I, Hamilton JK, Ho J, Ball GCD, Mian R, Buchholz A, Laberge AM, Legault L, Tremblay MS, Chanoine JP, Thabane L, Morrison KM. Individual and family characteristics associated with health indicators at entry into multidisciplinary pediatric weight management: findings from the CANadian Pediatric Weight management Registry (CANPWR). International Journal of Obesity 2021 Sep 9. [online ahead of print].
  • Zahn K, Ibrahim Q, Ball GDC, Buchholz A, Hamilton J, Ho J, Laberge AM, Legault L, Tremblay MS, Zenlea I, Thabane L, Chanoine JP, Morrison KM. Variability in how Canadian pediatric weight management clinics deliver care: evidence from the CANadian Pediatric Weight Management Registry. Childhood Obesity 2021;17(6):420-426.
  • Kao KT, Ferguson EC, Blair G, Chadha NK, Chanoine JP. Risk factors for the development of hypocalcemia in pediatric patients after total thyroidectomy - a systematic review. International Journal of Pediatric Otorhinolaryngoly 2021;143:110666.
  • Cuvelier GDE, Li A, Drissler S, Kariminia A, Abdossamadi S, Rozmus J, Chanoine JP, Ng B, Mostafavi S, Brinkman RR, Schultz KR. Age related differences in the biology of chronic graft-versus-host disease after hematopoietic stem cell transplantation. Frontiers in Immunology 2020;11:571884.
  • Kalaitzoglou E, Majaliwa E, Zacharin M, de Beaufort C, Chanoine JP, van Wijngaard-DeVugt C, Sperla E, Boot AM, Drop SLS. Multilingual global e-learning pediatric endocrinology and diabetes curriculum for front line health care providers in resource-limited countries: development study. Journal of Medical Internet Research: Formative Research 2020;4(11):e18555.
  • Glackin S, Metzger DL, Hanas R, Chanoine JP. Is age a risk factor for cerebral edema in children with diabetic ketoacidosis? A literature review. Canadian Journal of Diabetes 2020;44(1):111–118.
  • von Oettingen JE, Craven M, Duperval R, Sine St Surin F, Eveillard R, Saint Fleur R, Van Vliet G, Chanoine JP, Louis R. Experience With store-and-forward consultations in providing access to pediatric endocrine consultations in low- and middle-income countries. Frontiers in Public Health 2019;7:272.
  • Adekoya AO, Fetuga MB, Jarrett OO, Ogunlesi TA, Chanoine JP, Adekoya AO. Clitoral sizes and anogenital distances in terms infants in Nigeria. International Journal of Pediatric Endocrinolology 2019:5.
  • Gray NJ, Chanoine JP, Farmer MY, Jarvis JD, Armstrong K, Barr RD, et al. NCDs and the WHO Essential Medicines Lists: Children need universal health coverage too. Lancet Child and Adolescent Health 2019;3(11):756–757.
  • Ahmad N, Abosoudah IF, Sobaihi MM, Algiraigri AH, Roujouleh F, Ghurab F, Chanoine JP. Adrenal function following acute discontinuation of glucocorticoids in children with acute lymphocytic leukemia: A prospective study. Pediatric Hematolology and Oncology 2019;36(7):422-431.
  • Adekoya AO, Fetuga MB, Jarrett OO, Ogunlesi TA, Chanoine JP, Oba-Daini OO. Normative data on penile and ano-genital measurements of term male infants in Sagamu, Nigeria. Acta Paediatrica 2019;108(11):2041–2047.
  • Ameyaw E, Asafo-Agyei SB*, Hughes IA, Zacharin M, Chanoine JP. Incidence of disorders of sexual development in neonates in Ghana: prospective study. Archives of Disease in Childhood 2019;104(7):636-638.
  • Farnesi BC, Perez A, Holt NL, Morrison KM, Gokiert R, Legault L, Chanoine JP, Sharma AM, Ball GDC. Continued attendance for paediatric weight management: A multicentre, qualitative study of parents' reasons and facilitators. Clinical Obesity 2019;9(3):e12304.
  • Deal C, Kirsch S, Chanoine JP, Lawrence S, Cummings E, Rosolowsky ET, Marks SD, Jia N, Child CJ; GeNeSIS National Board on behalf of the GeNeSIS Canada Investigators. Growth hormone treatment of Canadian children: results from the GeNeSIS phase IV prospective observational study. CMAJ Open 2018;6(3):E372–E383.
  • Rowlands A, Ameyaw E, Rutagarama F, Dipesalema J, Majaliwa ES, Mbogo J, Ogle GD, Chanoine JP. Insights from the WHO and national lists of essential medicines: focus on pediatric diabetes care in Africa. Hormone Research in Paediatrics 2018;90(2):82–92.
  • Morrison KM, Ball GDC, Ho J, Mackie P, Buchholz A, Chanoine JP, Hamilton J, Laberge AM, Legault L, Thabane L, Tremblay M, Zenlea I. The CANadian Pediatric Weight management Registry (CANPWR): lessons learned from developing and initiating a national, multi-centre study embedded in pediatric clinical practice. BMC Pediatrics 2018;18(1):237.
  • Garde A, Chowdhury M, Rollinson AU, Johnson M, Prescod P, Chanoine JP, Ansermino JM, Dumont GA. A multi-week assessment of a mobile exergame intervention in an elementary school. Games Health Journal 2018;7(1):1–8.
  • Ahmad N, Chanoine JP. Consanguineous marriages and endocrine diseases in Arab societies. Pediatric Endocrinology Reviews 2017;15(2):159–164.
  • Perez AJ, Kebbe M, Holt NL, Gokiert R, Chanoine JP, Legault L, Morrison KM, Sharma AM, Ball GDC. Parent recommendations to enhance enrollment in multidisciplinary clinical care for pediatric weight management. Journal of Pediatrics 2018;192:122–129.
  • Team ABC3 Collaborators: Anderson LN, Ball GDC, Birken CS, Buchholz A, Carsley S, Chanoine JP, Clairman H, Dettmer E, Forhan M, Gehring ND, Hadjiyannakis S, Hamilton J, Hanning R, Haines J, Ho J, Holt NL, Kim THM, Legault L, Luca P, Maguire JL, Maximova K, McPherson AC, Morrison KM, Mâsse LC, Parkin PC, Perez A, Sprague AE, Toulany A, Tremblay MS, Tu K. The Team to Address Bariatric Care in Canadian Children (Team ABC3): Team grant research proposal. BioMed Central Research Notes 2017;10(1):301.
  • Asafo-Agyei SB, Ameyaw E, Chanoine JP, Zacharin M, Nguah SB, Jarrett OO. Anogenital distance in term newborns in Kumasi, Ghana. Hormone Research in Paediatrics 2017;88(6):396–400.
  • Fan E, Skippen PW, Sargent MA, Cochrane DD, Chanoine JP. Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured. Child's Nervous System 2017;33(12):2205–2207.
  • Kranenburg LJC, Reerds STH, Cools M, Alderson J, Muscarella M, Magrite E, Kuiper M, Abdelgaffar S, Balsamo A, Brauner R, Chanoine JP, Deeb A, Fechner P, German A, Holterhus PM, Juul A, Mendonca BB, Neville K, Nordenstrom A, Oostdijk W, Rey RA, Rutter MM, Shah N, Luo X, Grijpink K, Drop SLS. Global application of the assessment of communication skills of paediatric endocrinology fellows in the management of differences in sex development using the ESPE E-learning.org portal. Hormone Research in Paediatrics 2017;88(2):127–139.
  • Asafo-Agyei SB, Ameyaw E, Chanoine JP, Zacharin M, Nguah SB. Clitoral size in term newborns in Kumasi, Ghana. International Journal of Pediatric Endocrinology 2017;2017:6.
  • Rowlands A, Acosta-Gualandri A, Guevara-Aguirre J, Chanoine JP. WHO and national lists of essential medicines in Mexico, Central and South America, and the Caribbean: are they adequate to promote paediatric endocrinology and diabetes care? BMJ Global Health 2016;1(3):e000114.
  • Tu AW, Watts AW, Chanoine JP, Panagiotopoulos C, Geller J, Brant R, Barr SI, Mâsse L. Does parental and adolescent participation in an e-health lifestyle modification intervention improves weight outcomes? BMC Public Health 2017;17(1):352.
  • Asafo-Agyei SB, Ameyaw E, Chanoine JP, Nguah SB. Normative penile anthropometry in term newborns in Kumasi, Ghana: a cross-sectional prospective study. International Journal of Pediatric Endocrinology 2017;2017:2.
  • Dhaliwal J, Perez AJ, Holt NL, Gokiert R, Chanoine JP, Morrison KM, Legault L, Sharma AM, Ball GDC. Why do parents discontinue health services for managing paediatric obesity? A multi-centre, qualitative study. Obesity Research & Clinical Practice 2017;11(3):335–343.
  • Woo P, Murthy G, Wong C, Hursh B, Chanoine JP, Elango R. Assessing resting energy expenditure in overweight and obese adolescents in a clinical setting: validity of a handheld indirect calorimeter. Pediatric Research 2017;81:51–56.
  • Trivedi A, Babic S, Heiman M, Gibson WT, Chanoine JP1. Ghrelin, ghrelin O-acyltransferase, and carbohydrate metabolism during pregnancy in calorie-restricted mice. Hormone and Metabolic Research 2017;49(1):64–67.
  • Hursh BE, Fazeli M, Wang S, Marchant E, Woo P, Elango R, Lavoie P, Chanoine JP, Collet JP. Cardiac autonomic function at baseline and under stress and its relationship to circulatory markers of inflammation in obese compared to nonobese children: a pilot study. Hormone Research in Paediatrics 2016;85(5):339–346.
  • Garde A, Umedaly A, Abulnaga SM, Junker A, Chanoine JP, Johnson M, Ansermino JM, Dumont GA. Evaluation of a novel mobile exergame in a school-based environment. Cyberpsychology, Behavior and Social Networking 2016;19(3):186–192.
  • Hadjiyannakis S, Buchholz A, Chanoine J-P, Jetha MM, Gaboury L, Hamilton J, Birken C, Morrison KM, Legault L, Bridger T, Cook SR, Lyons J, Sharma AM, Ball GDC. The Edmonton Obesity Staging System for Paediatrics: a proposed clinical staging system for paediatric obesity. Paediatrics & Child Health 2016;21(1):21–26.
  • Perez AJ, Avis JL, Holt NL, Gokiert R, Chanoine JP, Legault L, Morrison KM, Sharma AM, Ball GD. Why do families enrol in paediatric weight management? A parental perspective of reasons and facilitators. Child: Care, Health and Development 2016;42(2):278-287.
  • Tremblay MS, Feng M, Garriguet D, Ball GD, Buchholz A, Chanoine JP, Lambert M, Morrison KM. Canadian Pediatric Weight Management Registry (CANPWR): baseline descriptive statistics and comparison to Canadian norms. BMC Obesity 2015;2:29.
  • Garde A, Umedaly A, Abulnaga SM, Robertson L, Junker A, Chanoine JP, Ansermino JM, Dumont GA. Assessment of a mobile game ("MobileKids Monster Manor") to promote physical activity among children. Games for Health Journal 2015;4(2):149-158.
  • Larrivée-Vanier S, Magne F, Patey N, Chanoine JP, Vuissoz JM, Van Vliet G, Deladoëy J. Conserved telomere length in human ectopic thyroids: an argument against premature differentiation causing arrested migration. Thyroid 2015;25(9):1050-1054.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C. Use of growth charts in Canada: a National Canadian Paediatric Surveillance Program survey. Paediatrics & Child Health 2015;20(4):185–188.
  • Perez A, Holt N, Gokiert R, Chanoine JP, Legault L, Morrison K, Sharma A, Ball G. Why don't families initiate treatment? A qualitative multicentre study investigating parents' reasons for declining paediatric weight management. Paediatrics & Child Health 2015;20(4):179-184.
  • Harel S, Cohen ASA, Hussain K, Flanagan SE, Schlade-Bartusiak K, Patel M, Courtade J, Li JBW, Van Karnebeek C, Kurata H, Ellard S, Chanoine JP, Gibson WT. Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture. Journal of Pediatric Endocrinology 2015 Jan 20. [Epub ahead of print].
  • Mâsse LC, Watts AW, Barr SI, Tu AW, Panagiotopoulos C, Geller J, Chanoine JP. Individual and household predictors of adolescents' adherence to a web-based intervention. Annals of Behavioral Medicine 2014 Oct 1. [Epub ahead of print].
  • Trivedi A, Babic S, Heiman M, Gibson WT, Chanoine JP. Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice. Peptides 2015;65(3):29–33.
  • Morrison KM, Damanhoury S, Buchholz A, Chanoine JP, Lambert M, Tremblay MS, Berall G, Hamilton J, Laberge AM, Legault L, Thabane L, Jakymyshyn M, Ambler KA, Ball GD. The CANadian Pediatric Weight management Registry (CANPWR): study protocol. BMC Pediatrics 2014;14:161.
  • Abu-Khudir R, Magne F, Chanoine JP, Deal C, Van Vliet G, Deladoëy J. Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands. Journal of Clinical Endocrinology and Metabolism 2014;99(6):E1120–1129.
  • Ngai YF, Sabatini P, Nguyen D, Davidson J, Chanoine JP, Devlin AM, Lynn FC, Panagiotopoulos C. Quetiapine treatment in youth is associated with decreased insulin secretion. Journal of Clinical Psychopharmacology 2014;34(3):359–364..
  • Rosa Fortin MM, Brown C, Ball GD, Chanoine JP, Langlois MF. Weight management in Canada: an environmental scan of health services for adults with obesity. BioMed Central Health Services Research 2014;14:69.
  • Santos RG, Durksen A, Rabbanni R, Chanoine JP, Lamboo Miln A, Mayer T, McGavock JM. Effectiveness of peer-based healthy living lesson plans on anthropometric measures and physical activity in elementary school students: a cluster randomized trial. JAMA Pediatrics 2014;168(4):330–337.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C, on behalf of the Canadian Pediatric Endocrine Group. Canadian Pediatric Endocrine Group extension to WHO growth charts: why bother? Paediatrics & Child Health 2013;18(6):295–297.
  • Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF Jr, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. American Journal of Human Genetics 2013;92(5):725–743.
  • Sharkia M, Michaud S, Berthier MT, Giguère Y, Stewart L, Deladoëy J, Deal C, Van Vliet G, Chanoine JP. Thyroid function from birth to adolescence in Prader–Willi Syndrome. Journal of Pediatrics 2013;163(3):800–805.
  • Jogova M, Song JES, Campbell AC, Warburton D, Warshawski T, Chanoine JP. Process evaluation of the Living Green, Healthy and Thrifty (LiGHT) web-based child obesity management program: combining health promotion with ecology and economy. Canadian Journal of Diabetes 2013;37(2):72–81.
  • Zacharin M, Chanoine JP, Cassorla F, Brink S, Hanas R, Fideleff HL, Oduwole A, Shah N, Hochberg Z. Promoting excellence in the care of pediatric endocrine diseases in the developing world. Pediatrics 2013;131(2):e573–578.
  • Ball GD, Perez Garcia A, Chanoine JP, Morrison KM, Legault L, Sharma AM, Gokiert R, Holt NL. Should I stay or should I go? Understanding families' decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study. BMC Health Services Research 2012;12:486, 8 pages.
  • Campbell AC, Barnum D, Ryden V, Ishkanian S, Stock S, Chanoine JP. The effectiveness of the implementation of HealthyBuddies™, a school-based, peer-led health promotion program in elementary schools. Canadian Journal of Diabetes 2012;36(4):181–186.
  • Panagiotopoulos C, Ronsley R, Al-Dubayee M, Brant R, Kuzeljevic B, Rurak E, Cristall A, Marks G, Sneddon P, Hinchliffe M, Chanoine JP, Mâsse LC. The Centre for Healthy Weights—Shapedown BC: A family-centered, multidisciplinary program that reduces weight gain in obese children over the short-term. International Journal of Environmental Research and Public Health 2011;8(12):4662–4678.
  • Vandernoot I, Sartelet H, Abu-Khudir R, Chanoine JP, Deladoëy J. Evidence for calcitonin-producing cells in human lingual thyroids. Journal of Clinical Endocrinology and Metabolism 2012;97(3):951–956.
  • Trivedi A, Babic S, Chanoine JP. Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay. Clinical Biochemistry 2012:45(1–2):178–180.
  • Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. Journal of Clinical Endocrinology and Metabolism 2011;96(11):E1771–1781.
  • Pradniuk M, Chanoine JP, Goldman RD. Obesity and physical activity in children. Canadian Family Physician 2011:57(7):779–782.
  • Chanoine JP, Richard M. Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo. International Journal of Pediatric Obesity 2011;6(2):95–101.
  • Ball GD, Ambler KA, Chanoine JP. Pediatric weight management programs in Canada: where, what and how? International Journal of Pediatric Obesity 2011;6(2–2):e58–e61.
  • Abu-Khudir R, Paquette J, Lefort A, Libert F, Chanoine JP, Vassart G, Deladoëy J. Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands. Public Library of Science ONE 2010;5(10):e13420.
  • Ni H, De Waele K, Walia P, Chanoine JP. In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis. Pediatric Research 2010;67(6):609–613.
  • Rogovik AL, Chanoine JP, Goldman RD. Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity. Drugs 2010;70(3):335–346.
  • Gibson W, Liu J, Gaylinn B, Thorner MO, Meneilly GS, Babich SL, Thompson D, Chanoine JP. Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin, and adiponectin in pregnant women with diabetes. Metabolism 2010;59(6):841–847.
  • Ni H, Walia P, Chanoine JP. Ontogeny of acylated ghrelin degradation in the rat. Peptides 2010;31(2):301–306.
  • Chanoine JP, Ball GCD, Hagedorn K, Morrison K. Fighting child and adolescent obesity: working towards national, integrated strategies. Canadian Jounal of Diabetes 2009;33(1):16–17 (editorial).
  • Dewan T, Chanoine JP. Body mass index in children with Prader-Willi Syndrome during human growth hormone therapy: a real world situation (letter). Journal of Pediatrics 2009;154(5):777–778.
  • Chanoine JP, De Waele K, Walia P. Ghrelin and the growth hormone secretagogue receptor in growth and development. International Journal of Obesity 2009;33(Suppl 1):S48–52.
  • Tham E, Liu J, Innis S, Thompson D, Gaylinn BD, Bogarin R, Haim A, Thorner MO, Chanoine JP. Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. American Journal of Physiology Endocrinology and Metabolism 2009;296(5):E1093–1100.
  • Bogarin R, Chanoine JP. Efficacy, safety and tolerability of orlistat, a lipase inhibitor, in the treatment of adolescent weight excess. Therapy 2009;6(1):23–30.
  • Haim A, Chanoine JP, Albersheim S, Mock T. Elevated free thyroxin levels following low molecular weight heparin treatment in a premature neonate. Acta Paediatrica 2008;97(12):1601.
  • Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatric Research 2009;65(1):39–44.
  • De Waele K, Ishkanian SL, Bogarin R, Miranda CA, Ghatei MA, Bloom SR, Pacaud D, Chanoine JP. Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome. European Journal of Endocrinology 2008;159(4):381–388.
  • Chanoine JP, Mackelvie KJ, Barr SI, Wong ACK, Meneilly GS, Elahi DH. GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise. Obesity 2008;16(1):202–204.
  • Stock S, Miranda C, Evans S, Plessis S, Ridley J, Yeh S, Chanoine JP. Healthy Buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary school.Pediatrics 2007;120(4):e1059–1068.
  • Bretherick KL, Metzger DL, Chanoine JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics Part A 2007;143(9):945–951.
  • Mackelvie KJ, Meneilly GS, Elahi D, Wong AC, Barr SI, Chanoine JP. Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin. Journal of Clinical Endocrinology and Metabolism 2007;92(2):648–654.
  • Chanoine JP. (Editorial) Individual differences in the hormonal control of appetite: a step toward a (more) successful treatment of childhood overweight? Journal of Clinical Endocrinology & Metabolism 2006;91(8):2864–2866.
  • Chanoine JP, Wong ACK, Barrios V. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Hormone Research 2006;66(2):81–88.
  • Stock S, Leichner P, Wong ACK, Ghatei MA, Kieffer TJ, Bloom SR, Chanoine JP. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. Journal of Clinical Endocrinology and Metabolism 2005;90(4):2161–2168.
  • Chanoine JP. Ghrelin in growth and development. Hormone Research 2005;63(3):129–138.
  • Khashu M, Chessex P, Chanoine JP. Iodine overload and severe hypothyroidism in a premature neonate. Journal of Pediatric Surgery 2005;40(2):E1–E4.
  • Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. Journal of the American Medical Association 2005;293(23):2873–2883.
  • Hirsh D, Heinrichs C, Leenders B, Wong ACK, Cummings DE, Chanoine JP. Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release. Hormone Research 2005;63(3):111–118.
  • Brooks BP, Kleta R, Stuart C, Tuchman M, Jeong A, Stergiopoulos SG, Bei T, Bjornson B, Russell L, Chanoine JP, Tsagarakis S, Kalsner L, Stratakis C. Genotypic heterogeneity and clinical phenotype in triple A syndrome: a review of the NIH experience 2000–2005. Clinical Genetics 2005;68(3):215–221.
  • Chanoine JP, Wong ACK. Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting. Endocrinology 2004;145(8):3813–3820.
  • Chanoine JP, Wong ACK, Lavoie JC. Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat. BioFactors 2004;20(2):109–118.
  • Yeung LP, Wong AC, Wang X, Birmingham CL, Lewicka S, Chanoine JP. Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates. Pediatric Research 2003;53(6):1019–1024.
  • Chanoine JP, Yeung LPK, Wong, ACK. Umbilical cord ghrelin concentrations in Asian and Caucasian neonates. Hormone Research 2003;60(3):116–120.
  • Farquhar J, Heiman M, Wong ACK, Wach R, Chessex P, Chanoine JP. Elevated umbilical cord ghrelin concentrations in small for gestational age neonates. Journal of Clinical Endocrinology & Metabolism 2003;88(9):4324–4327.
  • Panagiotopoulos C, Preston JM, Stewart LL, Metzger DL, Chanoine JP. Weekly telephone contact by a diabetes educator in adolescents with type 1 diabetes. Canadian Journal of Diabetes 2003;27(4):422–427.
  • Chanoine JP. Selenium and thyroid function in infants, children and adolescents. BioFactors 2003;19(3–4):137–143.
  • Chanoine JP, Yeung LP, Wong AC, Birmingham CL. Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone. Journal of Pediatric Gastroenterology and Nutrition 2002;35(3):282-286.
  • Chanoine JP, Néve J, Wu S, Vanderpas J, Bordeaux P. Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidism. Journal of Clinical Endocrinology & Metabolism 2001;86(3):1160–1163.
  • Huemer C, Kitson H, Malleson PN, Sanderson S, Huemer M, Cabral DA, Chanoine JP, Petty RE. Lipodystrophy in patients with juvenile dermatomyositis—evaluation of clinical and metabolic abnormalities. Journal of Rheumatology 2001;28(3):610–615.
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2001;15(5):297–301.
  • Chanoine JP, Compagnone NA, Wong AC, Mellon SH. Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis. BioFactors 2001;14(1–4):229–238.
  • Cheng PS, Chanoine JP. Should the definition of micropenis vary according to ethnicity? Hormone Research 2001;55(6):278–281.
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2000;14(11):915–918.
  • Chanoine JP, Rebuffat E, Kahn A, Van Vliet G. Decreased growth hormone response to glucagon in infants after an apnea of infancy. Journal of Pediatrics 1998;132(3):452–454.
  • Chanoine JP. Iodine intake is a main determinant of thyroid hypersensitivity to acute iodine overload. Clinical Pediatrics (Phila) 1998;37(3):212–213.
  • Lagrou K, Xhrouet-Heinrichs D, Heinrichs C, Craen M, Chanoine JP, Malvaux P, Bourguignon JP. Age-related perception of stature, acceptance of therapy, and psychosocial functioning in human growth hormone-treated girls with Turner's syndrome. Journal of Clinical Endocrinology & Metabolism 1998;83(5):1494–1501.

 
  • Bauer GR, Lawson ML, Metzger DL, for the Trans Youth CAN! Research Team. Do clinical data from transgender adolescents support the phenomenon of "rapid-onset gender dysphoria"? Journal of Pediatrics 15 November 2021 [advanced publication].
  • Lai CMB, Setiadi A, Barlas A, Kanani A, Pourshahnazari P, Leitch HA, CAUSES Study, Metzger DL, Merkeley H, Biggs CM. Targeted treatment of immune thrombocytopenia in CTLA4 insufficiency: a case report. British Journal of Haematology 10 October 2021 [advanced publication].
  • Bauer GR, Pacaud D, Couch R, Metzger DL, Gale L, Gotovac S, Mokashi A, Feder S, Raiche J, Nixon Speechley K, Temple Newhook J, Ghosh S, Pullen Sansfaçon A, Susset F, Lawson ML, for the Trans Youth CAN! Research Team. Transgender youth referred to clinics for gender-affirming medical care in Canada. Pediatrics 2021;148(5):e2020047266.
  • Alsaeed H, Metzger DL, Blydt-Hansen TD, Rodd CJ, Sharma A. Isolated diastolic high blood pressure: a distinct clinical phenotype in US children. Pediatric Research 2021;90(4):903–909.
  • D’Alessandro PR, Hamilton J, Khatchadourian K, Lunaczek-Motyka E, Schultz KR, Metzger DL, Deyell RJ. Precocious puberty: a red flag for malignancy in childhood. BC Medical Journal 2021;63(6):242–246.
  • Robinson SK, Rodd CJ, Metzger DL, Sharma AK. Prevalence of high blood pressure among Canadian children: 2017 American Academy of Pediatric guidelines with the Canadian Health Measures Survey. Paediatrics & Child Health 2021;26(3):e158–e165.
  • McGregor S, Metzger DL, Amed S, Goldman RD. Fluid management in children with diabetic ketoacidosis. Canadian Family Physician 2020;66(11):817-819.
  • Solimano A, Osiovich H, Kwan E, Metzger DL, Everett R. Are there alternatives to over-the-counter diabetes-care dextrose-gels for transitional neonatal hypoglycemia? Paediatrics & Child Health 2021;26(1):4–7.
  • Ronsley R, Islam N, Kang M, Nadel H, Reilly C, Metzger DL, Selby K, Panagiotopoulos C. Effects of bisphosphonate therapy on bone mineral density in boys with Duchenne muscular dystrophy. Clinical Medicine Insights: Endocrinology and Diabetes 2020;13:1–8.
  • Glackin S, Metzger DL, Hanas R, Chanoine JP. Is age a risk factor for cerebral edema in children with diabetic ketoacidosis? A literature review. Canadian Journal of Diabetes 2020;44(1):111–118.
  • Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group [Metzger DL, Study Group Member]. A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk. Diabetes Care 2018;41(9):1887–1894.
  • Guan L, Metzger DL, Lavoie PM, Collet JP. Glucose control and autonomic response during acute stress in youth with type 1 diabetes: a pilot study. Pediatric Diabetes 2018;19(5):1020–1024.
  • Sharma AK, Metzger DL, Rodd CJ. Increased prevalence and severity of high blood pressures in children using the 2017 AAP guidelines: a case-control study to characterize the new disease burden. JAMA Pediatrics 2018;172(6):557-565.
  • Rodd CJ, Metzger DL, Sharma AK. WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting. Paediatrics & Child Health 2018;23(3):176–178.
  • Ronsley R, Islam N, Ronsley C, Metzger DL, Panagiotopoulos C. Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital. Pediatric Diabetes 2018;19(2):333–338.
  • Writing Group for the TRIGR Study Group [Metzger DL, Study Group Member]. Effect of hydrolyzed infant formula vs conventional formula on risk of type 1 diabetes: the TRIGR randomized clinical trial. JAMA 2018;319(1):38–48.
  • Wong EM, Lehman A, Acott P, Gillis J, Metzger DL, Sirrs S. Hypogonadotropic hypogonadism in males with glycogen storage disease type 1. Journal of Inherited Metabolic Disorders Reports 2017:36:79–84.
  • Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Yea XC, Zhang LH, Bhavsar AP, Lee JJY, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger DL, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD. Exome sequencing and the management of neurometabolic disorders. New England Journal of Medicine 2016;374(23):2246–2255.
  • Daly AF, Yuan B, Fina F, Caberg J-H, Trivellin G, Rostomyan L, de Herder WW, Naves LA, Metzger DL, Cuny T, Rabl W, Shah N, Jaffrain-Rea M-L, Zatelli MC, Faucz FR, Castermans E, Nanni-Metellus I, Lodish M, Muhammad A, Palmeira L, Potorac I, Mantovani G, Neggers SJ, Klein M, Barlier M, Liu P, Ouafik L, Bours V, Lupski JR , Stratakis CA, Beckers A. Somatic mosaicism underlies X-linked acrogigantism (XLAG) syndrome in sporadic male subjects. Endocrine-Related Cancer 2016;23(4):221–233.
  • Sharma AK, Metzger DL, Daymont C, Hadjiyannakis S, Rodd CJ. LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks. Pediatric Research 2015;78(6):723–729.
  • Veale J, Saewyc E, Frohard-Dourlent H, Dobson S, Clark B and the Canadian Trans Youth Health Survey Research Group. Being Safe, Being Me: Results of the Canadian Trans Youth Health Survey. Vancouver, BC: Stigma and Resilience Among Vulnerable Youth Centre, School of Nursing, University of British Columbia 2015 (Co-Investigator).
  • Beckers A, Lodish MB, Trivellin G, Rostomyan L, Lee M, Faucz FR, Yuan B, Choong CS, Caberg J-H, Verrua E, Naves LA, Cheetham TD, Young J, Lysy PA, Petrossians P, Cotterill A, Shah NS, Metzger DL, Castermans E, Ambrosio MR, Villa C, Strebkova N, Mazerkina N, Gaillard S, Barcelos Barra G, Casulari LA, Neggers SJ, Salvatori R, Jaffrain-Rea M-L, Zacharin M, Lecumberri Santamaria B, Zacharieva S, Lim EM, Mantovani G, Zatelli MC, Collins MT, Bonneville J-F, Quezado M, Chittiboina P, Oldfield EH, Bours V, Liu P, de Herder WW, Pellegata N, Lupski JR, Daly F, Stratakis, CA. X-linked acrogigantism (X-LAG) syndrome: clinical profile and therapeutic responses. Endocrine-Related Cancer 2015;22(3):353–367.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C. Use of growth charts in Canada: a National Canadian Paediatric Surveillance Program survey. Paediatrics & Child Health 2015;20(4):185–188.
  • Lawrence SE, Cummings EA, Pacaud D, Lynk A, Metzger DL. Joint Position Statement from the Canadian Paediatric Society and the Canadian Pediatric Endocrine Group. Managing type 1 diabetes in school: recommendations for policy and practice. Paediatrics & Child Health 2015:20(1):35–39.
  • Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. New England Journal of Medicine 2014;371(25):2363–2374.
  • Li D, Opas EE, Tuluc F, Metzger DL, Hou C, Hakonarson H, Levine MA. Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization. Journal of Clinical Endocrinology and Metabolism 2014;99(9):E1774–1783.
  • Hasan H, Howard AF, Metzger DL, Gill S, Johnson M, Lo AC, Goddard K. Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height. British Columbia Medical Journal 2014;56(5):230–235.
  • Hasan H, Howard F, Morgan SG, Metzger DL, Lo AC, Goddard K. Provincial disparities of growth hormone coverage for adult survivors of paediatric brain tumours across Canada. Healthcare Policy 2014;9(3):80–96.
  • Khatchadourian K, Amed S, Metzger DL. Clinical management of youth with gender dysphoria in Vancouver. Journal of Pediatrics 2014;164(4):906–911.
  • Rodd C, Metzger DL, Sharma A, for the Canadian Pediatric Endocrine Group Working Committee for National Growth Charts. Extending WHO weight-for-age reference curves to older children. BMC Pediatrics 2014;14:32.
  • Cheung SSC, Ou D, Metzger DL, Meloche M, Ao Z, Ng SSW, Owen D, Warnock GL. B7-H4 expression in normal and diseased human islet β cells. Pancreas 2014;43(1):128–134.
  • Inman M, Hursh BE, Mokashi A, Pinto T, Metzger DL, Cummings EA. Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty. Hormone Research in Paediatrics 2013;80(1):64–68.
  • Lawrence S, Cummings E, Chanoine J-P, Metzger DL, Palmert M, Sharma A, Rodd C, on behalf of the Canadian Pediatric Endocrine Group. Canadian Pediatric Endocrine Group extension to WHO growth charts: why bother? Paediatrics & Child Health 2013;18(6):295–297.
  • Malhotra N, Khatchadourian K, Metzger DL, Lam JM. Clinician’ Corner. Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones. Paediatrics & Child Health 2013;18(2):91–93.
  • Wang X, Hao J, Metzger DL, Mui A, Lee I-F, Akhoundsadegh N, Ao Z, Chen L, Ou D, Verchere CB, Warnock GL. Endogenous expression of B7-H4 improves long term murine islet allograft survival. Transplantation 2013;95(1):94–99.
  • Wang X, Hao J, Metzger DL, Mui A, Lee I-F, Akhoundsadegh N, Chen LC, Ou D, Ao Z, Verchere CB, Warnock GL. Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival. Islets 2012;4(4):1–12.
  • Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano L, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF Jr., Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GNRH receptor (GNRHR). Journal of Clinical Endocrinology and Metabolism 2012;97(9):E1798–E1807.
  • Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. B7-H4 induces donor-specific tolerance in mouse islet allografts. Cell Transplantation 2012;21(1):99–111.
  • Wang X, Metzger DL, Meloche M, Hao J, Ao Z Warnock GL. Generation of transplantable beta cells for patient-specific cell therapy. International Journal of Endocrinology 2012;Article ID 414812, 7 pages.
  • Wang X, Hao J, Metzger DL, Ao Z, Verchere CB, Chen L, Ou D, Mui A, Warnock GL. B7-H4 treatment of T cells inhibits ERK, JNK, and AKT activation. PLoS ONE 2012;7(1):e28232.
  • Wang X, Hao J, Metzger DL, Mui M, Ao Z, Akhoundsadegh N, Langermann S, Liu L, Chen L, Ou D, Verchere CB, Warnock GL. Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes 2011;60(12):3246–3255.
  • Wang X, Hao J, Metzger DL, Ao Z, Meloche M, Verchere CB, Chen L, Ou D, Mui AL, Warnock GL. B7-H4 pathway in islet transplantation and β-cell replacement therapies. Journal of Transplantation, 2011:Article ID 418902, 8 pages.
  • Levine DS, Metzger DL, Nadel HR, Oviedo A, Adam MJ, Skarsgard E. Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatric Radiolology 2011;41(10):1321–1325.
  • Amed S, Vanderloo SE, Metzger DL, Collet J-P, Reimer K, McCrea P, Johnson JA. Validation of diabetes case definitions using administrative claims data. Diabetic Medicine 2011;28(4):424–427.
  • Metzger DL. Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol. British Columbia Medical Journal 52(1):24–31, 2010.
  • Peñaherrera MS, Weindler S, Van Allen MI, Yong S-L, Metzger DL, McGillivray B, Boerkoel C, Langlois S, Robinson WP. Methylation profiling in individuals with Russell–Silver syndrome. American Journal of Medical Genetics Part A 152A(2):347–355, 2010.
  • Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation 2009;87(4):482–490.
  • Calado J, Sznajer Y, Metzger DL, Rita A, Hogan MC, Kattamis A, Scharf M, Tasic V, Greil J, Brinkert F, Kemper MJ, Santer R. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrology Dialysis Transplantation 2008;23(12):3874–3879.
  • Bretherick KL, Metzger DL, Chanoine JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. American Journal of Medical Genetics Part A 2007;143(9):945–951.
  • Pitteloud N, Acierno JS Jr, Meysing A, Eliseenkova AV, Ma J, Ibrahimi OA, Metzger DL, Hayes FJ, Dwyer AA, Hughes VA, Yialamas M, Hall JE, Grant E, Mohammadi M, Crowley WF Jr. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proceedings of the National Academy of Sciences of the USA 2006;103(16):6281–6286.
  • Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger DL, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. Journal of the American Society of Nephrology 2006;17(5):1429–1436.
  • Ou D, Wang X, Metzger DL, Ao Z, Pozzilli P, James RFL, Chen L, Warnock GL. Suppression of human T-cell responses to β cells by activation of B7-H4 pathway. Cell Transplantation 2006;15(5):399-410(12).
  • Skowronski DM, Bjornson G, Husain E, Metzger DL, Scheifele DW. Oculo-respiratory syndrome after influenza immunization in children. Pediatric Infectious Disease Journal 2005;24(1)63–69.
  • Cheung SS, Metzger DL, Wang X, Huang J, Tai J, Tingle AJ, Ou D. Tumor necrosis factor–related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus. Pancreas 2005;30(2):105–114.
  • Ou D, Wang X, Metzger DL, James RFL, Pozzilli P, Plesner A, Korneluk RG, Verchere CB, Tingle AJ. Synergistic inhibition of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human pancreatic β cells by Bcl-2 and X-linked inhibitor of apoptosis. Human Immunology 2005;66(3):274–284.
  • Grasberger H, Mimouni–Bloch A, Vantyghem M–C, van Vliet G, Abramowicz M, Metzger DL, Abdullatif H, Rydlewski C, Macchia PE, Scherberg NH, van Sande J, Mimouni M, Weiss RE, Vassart G, Refetoff S. Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci. Journal of Clinical Endocrinology and Metabolism 2005;90(7):4025-4034.
  • Ou D, Wang X, Metzger DL, Robbins M, Huang J, Jobin C, Chantler JK, James RFL, Pozzilli P, Tingle AJ. Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human β cells by Fas-associated death domain and nuclear factor κB. Human Immunology 2005;66(7):799-809.
  • Schlingmann KP, Sassen MC, Weber S, Pechmann U, Kusch K, Pelken L, Lotan D, Syrrou M, Prebble JJ, Cole DE, Metzger DL, Rahman S, Tajima T, Shu SG, Waldegger S, Seyberth HW, Konrad M. Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. Journal of the American Society of Nephrology 2005;16(10):3061–3069.
  • Ortiz–Alvarez O, Metzger DL, Malleson PN, Cabral DA, Tucker LB, Petty RE. Addison's disease in a child with systemic lupus erythematosus. Pediatric Rheumatology Online Journal 2004;2(2):134–139.
  • McKinney JL, Cao H, Robinson JF, Metzger DL, Cummings E, Riddell DC, Sanderson SR, Pacaud D, Ho J, Hegele RA. Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY). Clinical and Investigative Medicine 2004;27(3):129–134.
  • Metzger DL. Current approaches to the prevention of type 1 diabetes. British Columbia Medical Journal 2004;46(9):446–450.
  • Bradley TJ, Hosking MCK, Metzger DL, Sanatani S. Long on QT and low on calcium. Cardiology in the Young 2004;14(6):667–670.
  • Panagiotopoulos C, Preston JM, Stewart LL, Metzger DL, Chanoine JP. Weekly telephone contact by a diabetes educator in adolescents with type 1 diabetes. Canadian Journal of Diabetes 2003;27(4):422–427.
  • Ou D, Metzger DL, Wang X, Pozzilli P, Tingle AJ. β-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: autoaggressive CD56+ β cells by HLA-restricted and non-HLA-restricted pathways. Human Immunology 2002;63(4)256–270.
  • Cao H, Shorey S, Robinson J, Metzger DL, Stewart L, Cummings E, Hegele RA. GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young. Human Mutation 2002;20(6):478-479 (Mutation in Brief #561).
  • Ou D, Metzger DL, Wang X, Huang J, Pozzilli P, Tingle AJ. TNF-related apotosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 2002;45(12):1678–1688.
  • Diabetes Prevention Trial—Type 1 Diabetes Study Group [Metzger DL, Study Group Member]. Effects of insulin in relatives of patients with type 1 diabetes mellitus. New England Journal of Medicine 2002;346(22):1685-1691.
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2001;15(5):297–301.
  • Sandrini F, Farmakidis C, Kirschner LS, Wu S-M, Tullio-Pelet A, Lyonnet S, Metzger DL, Bourdony CJ, Tiosano D, Chan W-Y, Stratakis CA. Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticosteroids. Journal of Clinical Endocrinology & Metabolism 2001;86(11):5433–5437.
  • Zhang Y-H, Huang B-L, Anyane-Yeboa K, Carvahlo JAR, Clemons RD, Cole T, De Figueiredo BC, Lubinsky M, Metzger DL, Quadrelli R, Repaske DR, Reyno S, Seaver LH, Vaglio A, Van Vliet G, McCabe LL, McCabe ERB, Phelan JK. Nine novel mutations in NRB01 (DAX1) causing adrenal hypoplasia congenita. Human Mutation 2001;18(6):547 (Mutation in Brief #463).
  • Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase. Canadian Journal of Gastroenterology 2000;14(11):915–918.
  • Bjornson G, Scheifele D, Metzger DL, Ferguson A, Wensley D, Whitfield M. Promoting the use of influenza vaccine for children at risk of complications. British Columbia Medical Journal 2000;42(2):89–90.
  • Ou D, Mitchell LA, Metzger DL, Gillam S, Tingle AJ.Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus. Diabetologia 2000;43(6):750–762.
  • Ou D, Jonson LA, Metzger DL, Tingle AJ. CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: implications for HLA class I and II allelic linkage to disease susceptibility. Human Immunology 1999;60(8):652–664.
  • Metzger DL, Kerrigan JR. Sex-steroid-hormone modulation of the somatotropic axis during normal male puberty. In: Veldhuis JD, Giustina A, eds. Serono Symposia USA: Sex-steroid interactions with growth hormone. New York: Springer-Verlag, 1999.
  • Travitz J, Metzger DL. Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues. Genetics in Medicine 1999;1(5):224–230.
  • Metzger DL. A provincial protocol for the treatment of diabetic ketoacidosis in children. British Columbia Medical Journal 1998;40(3):110–114.
  • Metzger DL, Kerrigan JR, Rogol AD. The short-term administration of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men. Journal of Clinical Endocrinology & Metabolism 1997;82(2):692–700.
  • Veldhuis JD, Metzger DL, Martha Jr. PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. Journal of Clinical Endocrinology & Metabolism 1997;82(10):3414–3420.
 

 
 

 
 

 
 

 
 

 
 

 
 

 
 
You can help

Support our research & education programs

The Endocrinology & Diabetes Unit participates in a number of research studies at the basic science, clinical and applied levels. Our publication list attests to the breadth of our active research interests. As well, we continue to develop and update educational materials for our patients. Funding for these efforts is derived from governmental and institutional grants, from industry support, and from private donations. These funds can be directed to the project area of the donor's choice.

Endocrine Educational Materials

Our unit has developed a number of booklets and handouts for our patients with endocrine conditions. Many of these resources are used extensively across North America.

Diabetes Educational Materials

Our unit has developed a number of booklets and handouts for our patients with type 1 and type 2 diabetes. Many of these resources are used extensively across North America. Two recent projects are entitled Insulin Dose Adjustment: An Online Education Program for Parents of Children with Diabetes and Taking Care of Diabetes at School.

Diabetes Basic-Science & Clinical Research

Members of our unit work in close collaboration with scientists from the BC Children's Hospital Research Institute. Our areas of focus include: genetics of type 1 diabetes; islet cell biology and transplantation; viral pathogenesis of diabetes; immunology of type 1 diabetes; and clinical diabetes research.

Obesity Basic-Science & Clinical Research

The Chanoine–Alimenti Endowment for Childhood Obesity was established to develop and enhance new research and clinical programs aimed at the prevention and treatment of childhood and adolescent obesity.

All cheques should me made out to the BC Children's Hospital Foundation. Please note on the cheque the specific cause or program for which you are making a donation. If you have further questions about contributing to the research and educational efforts that are being conducted by our division, please contact:

Ms. Janice Williams
British Columbia's Children's Hospital Foundation
938 West 28th Avenue
Vancouver, BC V5Z 4H4 Canada
Phone: 604-875-2677
Fax: 604-875-2596
E-mail: jwilliams@bcchf.ca

We thank you for your interest in our research and educational activities!

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